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Business traveler thai massage Gangnam with vegetotherapy.org? Therapy Massage boasts a secure payment service that is different from other business establishments. Deposits or reservations are never received first, and we always insist on a deferred payment service. No need to worry, feel free to consult now. Just make a reservation and pay upon arrival. No deposit required for all course rates! All our masseuses have a good size profile in principle. We are confident in our massage skills and satisfaction with our services, and we are committed to providing you with the best experience during your service time. We take great pride in providing the best possible experience to all our guests. See additional details at https://vegetotherapy.org/.

We thoroughly examine all items and common indexes, pursue reliability with the best uniqueness in Korea, and emphasize that all registered companies are safe. ​In the event of a problem, vegetotherapy.org promptly takes after-sales measures and removes the company that causes the problem as soon as it is found. Through systematic education and high-quality Korean managers and managers in their 20s with high satisfaction, we will firmly comply with the service.

There are a myriad of companies these days, but safety verification should be mandatory and also honest. If you make a deposit or advance deposit to a company that provides a false profile for the sole purpose of short-term profit, you may be in for a big loss. Business trip massage vegetotherapy.org recommends to you only those companies that thoroughly implement the deferred payment system. How do I choose a secure and proven network? After consulting, you can select your region and course and use it quickly. A company with an unconditional thorough ​network is a safe place. There are so many sane places these days and they are very dangerous.

Who may benefit from Swedish massage therapy? If you’re looking for short-term pain relief and temporary relaxation, you could benefit from a Swedish massage. Long-term effects on pain and anxiety may possibly be achieved with regular sessions. Research from 2016 also identified massage as a better alternative to long-term pain medications. Other 2016 research has asserted that massage therapy is preferable to no treatment for chronic pain. While massage therapy is widely regarded as safe when done by a professional, risks still exist.

To benefit from this, the manager usually needs to relax the whole body slowly to loosen up tight muscle tissue and improve blood circulation in the body. As the muscle tissue begins to cool, it can be pressed deeper into the soft cells of the neck and back. Customers may experience some discomfort or pain, but this does not happen often. Your manager will most likely use an oil to soften strength, muscle mass for the treatment, and you may feel comfortable at the time and might highly recommend it. This is not the only real reaction to pain. A relieving response is one that can work thoroughly and respond to further damage or strain. Your manager can advise you to improve your comfort. It also helps to relax muscle mass. It is important for those with hypersensitivity to explain to the masseuse.

This energy is said to flow along specific meridians or paths, which are connected to our physical system. The goal of Asian massage is to relax, calm and heal the body through the harmonious release of stress and free-flowing energy. It is important to understand that there is not only one type of Asian massage. Instead, it is an umbrella term used to describe many massage themes originating in China, Japan, and other Asian countries. Many types of Asian massage are used today in therapeutic massage settings. As we await the spring and renewal season, now it is the right time to learn a little more about them.

One way to look at Jin Shin Jyutsu is to see it as an incredibly simple version of the acupressure massage. This is because it follows the same principles as acupressure, except that it focuses on only 26 points, which are less than the 300 points with which the acupressure works. These 26 points are called SELs, which stand for safety energy locks and are located along the energy pathways of the body. Using his hands, a Jin Shin Jyutsu practitioner will hold a combination of these SELs and gently massage through them, allowing the client to experience a flow of energy, which can be as comfortable as it is healing.

There are literally tons of massage options out there, with friendly and detailed explanations for those who have never had one before. We only hire and provide properly trained managers. The reason is to prevent potential problems for consumers in advance​We will take the lead for customer service content amid a swarm of unverified companies.​The selection process is very important. Customer complaints are remarkably low as only carefully selected locations are selected. For customer-oriented review content​, we promise to provide you with the most comfortable and beneficial business trip massage in Korea so that you can use it quickly and safely.

Did you know that there are other physiological effects? Massage can make us more relaxed by increasing endorphins and lowering cortisol will also happen because it lowers blood pressure! Advantages of business trip massage therapy: Business trip massage therapy has the advantage of improved sleep by reducing levels of cortisol, a stress hormone that can interfere with your ability to fall asleep at night. By raising oxytocin levels, oxytocin is known as the “kuddle” hormone, which helps you relax and feel calm. This increase in oxytocin also boosts your vitality, increases your confidence and makes you feel better connected with others.

For our Korean visitors:

출장안마 테라피 소개에서는 출장 서비스의 장점과 방문 및 출장 서비스를 통하여 직장에서 긴 하루를 보낸 후에 휴식을 취하는 훌륭한 방법입니다. 방문 및 출장마사지 서비스 제공의 목적과 효능은 다음과 같습니다. 테라피 출장안마는 마음, 몸, 그리고 영혼에 매우 이롭다. 혈액순환을 증가 시켜 근육과 피부에 영양을 공급하여 수분과 유연성을 유지시켜 신체에 좋습니다. 마사지는 콜라겐 생성을 촉진하여 피부 탄력을 개선하고 잔주름과 주름을 줄이는 데 도움을 줍니다. 그것은 또한 혈액 순환을 촉진해 눈 밑 다크서클의 외모를 줄이는 데 도움을 준다. 테라피 출장 마사지 치료사들은 몸과 마음을 매우 편안하게 해주는 특별한 경청자가 되도록 훈련받는다. 마사지는 피부와 근육에 영양분을 공급하기 때문에 당신의 피부를 빛나게 한다. 그것은 또한 여러분의 기분을 훨씬 더 좋게 만드는 혈액 순환을 돕습니다! 테라피 출장안마의 주요 기능 중 하나는 부상 후 회복이다.

마사지 오일과 로션을 바를 수도 있습니다. 그러나 천연 스킨 오일은 고객의 취향에 맞춰져 있습니다. 이러한 항목은 근육을 느슨하게 하고 손상이나 스트레스로 인한 피로도를 줄이는 데 도움이 됩니다.이점을 누릴 때 관리사는 일반적으로 뭉친 근육 조직을 풀어주고 인체의 혈액순환을 원활하게 하기 위해 전체를 천천히 이완시켜줘야 합니다. 근육 조직이 차가워지기 시작하기 때문에 목과 등의 부드러운 세포에 더 깊숙이 눌릴 수 있습니다. 고객은 약간의 불편함이나 통증을 경험할 수 있지만, 이는 자주 발생하지는 않습니다. 담당 관리사는 치료하기 위해 힘, 근육량을 부드럽게 하는 오일을 사용할 가능성이 높으며, 그 당시에는 편안함을 느껴서 강력히 추천할 수도 있습니다. 이것은 통증에 대한 유일한 실제 반응이 아닙니다. 완화 반응은 철저하게 작동할 수 있고 추가 손상이나 긴장에 대응할 수 있는 것입니다. 관리사사는 편안함을 개선하도록 조언할 수 있습니다. 또한 근육량을 이완시키는 데 도움이 됩니다. 과민증이 있는 분은 안마사에게 설명하는 것이 중요합니다.

다양한 유형의 아시아 마사지. 대부분의 아시아 마사지는 신체의 에너지 흐름과 함께 작동하는 기술을 사용합니다. 기본적으로 목표는 신체가 재설정될 수 있도록 내부 요소 또는 주기 내에서 균형을 만드는 것입니다. 이것은 대부분 휴식을 취하는 서양 마사지 기술과 대조됩니다. 두 번째 차이점은 아시안 마사지는 맨살에 테크닉을 적용하는 서양 마사지와 달리 옷을 다 차려입은 상태에서 할 수 있다는 것입니다.

테라피 출장마사지는 대한민국 최고의 출장 서비스를 제공한다고 자부합니다. 이용하시는 모든 고객에게 출장 마사지가 필요하시거나, 아니면 회사 일정으로 다른 지역으로 출장을 가야 할 때에도 저희는 항상 고객을 위해서 모든 서비스를 지원해드리는 특성이 있습니다. 손님이 원하시는 모든 시간에 상담할 수 있고 24시간 이용할 수 있으며 주말에도 정상적으로 운영 중이므로 연중무휴로 이용할 수 있음으로 언제라도 예약할 수 있습니다. 상담 전화로 연결하신다면 자세한 맞춤 출장 테라피 마사지의 서비스에 대한 특성을 설명해 드립니다. 출장 테라피의 정식 마사지 관리사들이 호텔 객실뿐만 아니라 집(또는 사무실)과 같은 개인 장소에서 이용할 수 있는 특성으로 손님 개개인의 프라이버시를 보장해 드립니다. 읽다 추가의 정보 여기 출장안마.

Jin Shin Jyutsu를 보는 한 가지 방법은 지압 마사지의 믿을 수 없을 정도로 간단한 버전으로 보는 것입니다. 지압이 작용하는 300포인트 미만인 26포인트에만 집중한다는 점만 빼면 지압과 같은 원리를 따르기 때문이다. 이 26개 지점을 SEL이라고 하며 이는 안전 에너지 잠금 장치를 의미하며 신체의 에너지 경로를 따라 위치합니다. 그의 손을 사용하여 Jin Shin Jyutsu 실무자는 이러한 SEL의 조합을 잡고 이를 통해 부드럽게 마사지하여 고객이 치유만큼 편안할 수 있는 에너지의 흐름을 경험할 수 있도록 합니다.

다른 유형의 마사지 요법과 마찬가지로 스웨덴식 마사지는 일시적으로 통증을 완화하고 긴장을 푸는 데 도움이 되는 방법으로 홍보됩니다. 다음은 스웨디시 마사지의 12가지 가능한 이점과 관련 임상 연구에 대한 정보입니다. 스웨디시 마사지가 요통에 도움이 될 수 있지만 그 이점에 대해 상충되는 과학적 증거가 있습니다. NCIH(National Center for Complementary and Integrative Health)에 따르면 일부 연구에 따르면 마사지 요법은 일반적으로 일시적인 완화 효과만 제공합니다. 2017년 한 리뷰에서는 스웨덴식 마사지가 간호사의 요통 완화에 실제로 도움이 된다고 밝혔습니다.

다른 생리학적 효과가 있다는 것을 알고 있었나요? 안마는 엔도르핀을 증가 시켜 우리를 더 이완되게 만들 수 있고 혈압도 낮추기 때문에 줄어든 코르티솔도 일어날 것입니다! 출장안마 테라피는 밤에 잠드는 당신의 능력을 방해할 수 있는 스트레스 호르몬인 코르티솔의 수치를 감소 시켜 향상된 수면의 장점이 있습니다. 옥시토신 수치를 높여주어 옥시토신은 긴장을 풀고 차분하게 느끼도록 도와주는 “커들” 호르몬으로 알려져 있습니다. 옥시토신의 이러한 증가는 또한 여러분의 활력을 증진하고, 여러분의 신뢰감을 증가시키며 다른 사람들과 더 잘 연결되어 있다고 느끼게 합니다.

출장안마 요금을 결제하실 때 모든 고객이 지켜야 할 주의 사항이 있습니다. 우선 검증되지않은 출장업체중에 예약 시 선입금 또는 처음 이용 고객이라서 보증금이 필수라며 갖가지 유인책들은 일삼으며 예약금을 먼저 요구하는 곳들은 피싱에 위험성이 높은 곳입니다. 상식적으로 생각했을 때 아직 출장 여자 관리사가 도착도 하지 않았는데 먼지 요금을 지불하라는 안내는 이해하기가 어렵습니다. 하지만 간혹 손님 중에 이러한 기본적인 사항을 가볍게 생각하고 속는 경우가 많습니다. 그러므로 보증된 출장안마를 선정할 때는 관리사 도착 후 직접 결제하는 방식의 예약비 없는 출장 업체만을 선택하고 이용하기를 당부드립니다. 꼭 필독하고 확인 과정을 주의하시길 당부합니다. 출장안마 테라피에서는 고객들이 지불하는 요금에 대한 합당한 서비스를 위해서 노력합니다.

Top rated spine stretching products? Lumbarest therapy for osteochondrosis: One of the most common diseases in which bone tissue is damaged is osteochondrosis. As mentioned earlier, Lumbarest therapy is an effective method for treating this disease, and that is why it is included in the main complex of physiotherapeutic treatment of osteochondrosis. In addition, it can be carried out during the rehabilitation period. The popularity of the method is due to the mild effect, which allows you to adjust the position of the spinal column, stop pain and improve the functioning of internal organs. In general, each session has a positive effect on the body of patients with osteochondrosis. Discover even more information at spine stretching products.

Many different types of non-surgical spinal decompression traction devices are available for purchase on the market nowadays. However, most of them are a pricey, high-tech kind of mechanical traction that, although it may give relief in certain instances of low back pain, is frequently advertised by manufacturers as a non-surgical method of correcting degenerative and herniated discs. On the contrary to the other, Lumbarest is based on natural treatment.

The influence of the treatment procedure on the condition of the test subject and the resting comfort were investigated by questionnaire. The tension in the long muscles of the back and the paravertebral musculature was evaluated by their firmness using a muscle tensiometer. The latter determines the force necessary to achieve a predetermined deformity of the muscle mass in the investigative region with the aid of an inventor tip. Additionally, the directional compression of the soft tissue was measured by this inventor placed perpendicularly over the skin. Finally, the force was measured, which is required to achieve a deformation of 4, 6, and 8 mm in the soft tissue but especially in the muscle tissue. Muscle tension was measured in the region of (spinous processes) T3, T6, and T16, as well as at L3, at a distance of 3-4 cm from the centerline of the spinal column before and after treatment.

Many zero gravity recliners for your home are powered, allowing you to recline at the touch of a button without having to move. When using one of these models, you can easily adjust the recliner to find the most comfortable position for your spine’s natural curve. Outdoor and indoor zero gravity chairs are normally unpowered in the zero gravity position. This means even a completely indoor zero gravity chair may miss some of the particular capabilities seen in zero gravity power recliners. Models suited for outdoor usage may feature additions like cup holders. While the health advantages of zero gravity chairs from neutral body orientation are obvious, classic zero gravity chairs are a more basic alternative than their zero gravity recliner siblings. Manual recliners exist, but the greatest zero gravity recliners are motorized and frequently provide luxury amenities like massage, thermal treatment, and smart wake-up routines. Though often more costly than the more basic outdoor and indoor zero gravity chairs stated above, zero electric gravity recliners add another degree of relaxation to your body.

Lumbarest therapy is a technique that allows you to eliminate pain in the back or lower back, is useful for curvature of the spinal column, causes relaxation of the muscles running along the back, decompression of the intervertebral discs, which leads to a decrease in hernias, removal of pinched nerve endings. Increase in intervertebral spaces, release pinched nerves, and straighten the spinal column. Reducing muscle and ligament tension, decreasing pressure on nerve endings due to an increase in intervertebral spaces. See even more information at https://www.lumbarest.com/.

Informatii profesionale oferite de psihologului Sibiu? Psihoterapia individuala este de un real ajutor intr-o multitudine de situatii, cateva dintre acestea fiind: cand ne confruntam cu probleme de comunicare, gestionarea stresului, probleme de relaționare, tulburări de somn, stimă de sine scăzută, fobii, pierderi și doliu, suicid, abuz, traumă, probleme de natură sexuală, dezvoltare personală etc. Dacă te-ai săturat de suferință, incertitudine, frică sau boală, înseamnă că a venit momentul schimbării! Uneori reușim singuri, alteori simțim nevoia de un sprijin pentru a putea merge mai departe. Citind aceste rânduri, te afli în locul potrivit iar decizia schimbării este aproape. Vedeti mai multe informatii in plus pe site-ul psihoterapie de cuplu Sibiu.

Varianta online presupune efectuarea sedintelor de psihoterapie individuala sau psihoterapie de cuplu de la distanta, in mediul online, prin aplicatii consacrate (cum ar fi Whats App ,Zoom sau Skype). Avantajele acestei forme de terapie sunt multiple: economisiti timpul si efortul destinat deplasarii la cabinet si va bucurati de beneficiile psihoterapiei din confortul locuintei dumneavoastra, spatiu cu care sunteti familiarizat si unde va simtiti in deplina siguranta.

In ceea ce priveste psihoterapia de familie,procesul terapeutic are loc intre psihoterapeut si membrii unei familii, fie ca este vorba despre membrii unei familii nucleare (soț, soție, copii) sau extinse (familie nucleară + alte rude și/sau alte generații). Dintre numeroasele beneficii amintim urmatoarele: familia poate fi ajutată să rezolve conflicte,să comunice eficient,să înlocuiască tipare disfuncționale de interacțiune moștenite cu unele armonioase, să stabilească granițe sănătoase între membrii familiei, dar și între familie și societate, să rezolve problemele intrafamiliale eficient și să facă față anumitor situații deosebite, precum decesul sau îmbolnăvirea gravă a unuia dintre membrii familiei.

Deci, când ar trebui să vizitezi un psiholog? Severitatea, persistența și gradul de interferență cu activitățile zilnice ale simptomelor tale te pot ajuta sa stii. De-a lungul vieții noastre, sau chiar zi de zi, cu toții putem experimenta o gamă largă de emoții și tulburări mentale, dar datorită rezistenței noastre înnăscute, ar trebui să fim capabili să ne adaptăm rapid și să recâștigăm stabilitatea emoțională și funcționalitatea mentală

Ce alte beneficii imi poate aduce psihoterapia individuala? Psihoterapia individuala este deosebit de utila si in depasirea neplacerilor cauzate de: Tulburări anxioase, cum ar fi Comportamentul Obsesiv-Compulsiv, Fobii, Atacuri de Panică sau Tulburări de Stres Post-traumatic; Dependențe, precum Dependența de Alcool, Dependența de droguri sau Dependența de jocuri de noroc; Alterarea dispoziției, când te confrunți cu Depresie sau Tulburare Bipolară; Tulburări alimentare, precum Anorexia sau Bulimia; Tulburări de personalitate, ca de exemplu Tulburare de Personalitate Dependentă; Tulburare de Personalitate Borderline. Vedeti multe informatii suplimentare aici https://psihologinsibiu.ro/.

Reliable Provestra online store today? Is Provestra Recommended for Post Menopausal Women? Provestra is suitable for menopausal and post-menopausal women who are experiencing other symptoms apart from a decreased sex drive. It helps balance your hormone levels and helps treat some of these inconvenient symptoms. Can a 28 year old female take Provestra? Or is it only for menopausal and post-menopause women? Provestra, an all-natural female libido enhancer, is highly endorsed by doctors to do what it does best, bring your boring sex back to life. This pill is made explicitly for women with a lack of sex activeness. It’s vital to inform your doctor to know if it’s safe enough to use Provestra supplement. See extra information at Provestra.

Here are some of the factors that could diminish the libido for women: hormonal imbalances: the period preceding menopause, can cause hormonal changes that will lead to a marked lack of interest in sexual activity. There may also be discomforts that occur during sexual contact due to decreased ability of vaginal tissues to lubricate the area. Depression and chronic stress: When you feel depressed or stressed, your libido can decrease greatly.

After orgasm, your muscles relax and your blood pressure drops. Your clitoris might feel particularly sensitive or even painful to touch. You might experience a refractory period, during which you won’t be able to orgasm again. Some people experience multiple orgasms, but that’s not necessary for you to have a pleasurable sexual experience. The most important thing is for you to listen to your body and be comfortable. You might struggle to concentrate on anything else — even if you’re not actually having sex! That’s because sexual stimuli activates certain changes in your brain, inducing certain sex-focused brain activity. However, there’s still a lot we don’t know about how the brain works, including how the brain works during sex.

Other female libido enhancers: Vigorelle : According to several studies , many women begin to lose their sexual desire as they get older, even before reaching the menopause. They view sex as more of an obligation than a pleasure and may start coming up with excuses to avoid it. The good news to these women is that there’s hope for a new life full of intimacy. Tiredness and headaches no longer need to be used as excuses, as Vigorelle puts you right in the mood for sex. Vigorelle is an all-natural libido enhancement cream for women by Leading Edge Health. It’s a topical cream that increases sexual arousal and acts as a lubricant for those who experience vaginal dryness. According to Leading Edge Health, Vigorelle is the perfect solution for women who want to bring intimacy back into their lives. It helps by: Acting as a lubricant to address vaginal dryness, Bringing your sexual groove back in an instant, Balancing the hormones, Having no side effects thanks to its all-natural ingredients.

Spanish Fly: Spanish Fly contains cantaridine, ie venomous bee sting! Iami! This piss is supposed to irritate your urinary tract and make you want to have sex. Although it seems like a method of medieval torture, it is one of the most popular aphrodisiacs in the world – and if it excited the people of the Middle Ages who slept in the mud and ate their own children, then it must be good for me too. Now it’s illegal in most countries, but hey babe, take a walk on the wild side. I went to the bar with my friends from work, but I didn’t go crazy and they started firing after the people around me. Disappointing. I would have liked. Spanish Fly was a total disappointment. But the packaging is cool, I have no idea.

What ingredients are in Provestra? Theobromine acts similar to caffeine in the body, a mild stimulant that widens blood vessels. It’s been used for centuries as an aphrodisiac. It’s commonly found in cocoa, chocolate, and tea leaves. Studies show that indole-3-carbinol can reduce the amount of estrogen in the body, which is helpful for those who have excess estrogen. Often, excess estrogen can cause a lower sexual drive. Indole-3-carbinol occurs naturally in many vegetables, such as cauliflower, turnips, and brussels sprouts. Ginseng is a root that has been used in Chinese medicine for centuries. Its properties have been shown to reduce hot flashes and night sweats in menopausal and perimenopausal women. Find even more details on https://provestrapills.com/.

Best rated depression counselling Melbourne? The combination of focusing-oriented somatic psychotherapy with talk therapy, our work together helps integrate the emotional landscape, as well as the body’s neurological nervous system. This integration allows for a shift in unhealthy habits, limiting patterns, and unhealthy boundaries, allowing the body’s nervous system to resolve itself back to its natural home – your authentic self. The body has its own internal wisdom. We are so accustomed to using our mind to navigate the word, that when guided correctly, we discover a whole world beneath the surface that is so often ignored. Using somatic based focusing psychotherapy we can tune in and truly listen, perhaps for the first time. This can create something truly profound. Find additional info at https://ronnieadamowicz.com/counselling-geelong/.

Nothing can replace the value of water. The body requires it to function. When you’re dehydrated, you can experience irritability, fatigue and confusion. Some people mistake symptoms of dehydration for symptoms of alcohol withdrawal. Water is important, but individuals should also consume beverages that contain electrolytes. Electrolytes are vital nutrients, including calcium, potassium and sodium. Alcohol intoxication and withdrawal can create electrolyte imbalances, which causes side effects such as muscle spasms, numbness and seizures. A healthy diet includes eating foods that contain the proper balance of carbohydrates, vitamins, minerals, proteins and fats. These nutrients help the brain and other organs function. If a person is malnourished, the body doesn’t have the energy it needs to recover from alcohol dependence.

A study conducted at the University of Utah suggested that “mindfulness may be linked to self-regulation throughout the day, and that this may be an important way that mindfulness contributes to better emotional and physical well-being.” According to Maria Camara, PhD, a psychotherapist who is also a qualified mindfulness teacher, meditation helps us connect with our true qualities. Once we’ve accepted who we are and learn to work with our thoughts directly, we reveal a loving capacity that has always been present within us. It’s no wonder that mindfulness increases happiness, enhances clarity and gives peace of mind.

Somatic Therapy around the world such as Somatic Experiencing in Australia, or Sensorimotor Psychotherapy in Australia is reshaping the therapy world. As a Somatic Therapy Melbourne Therapist, I will work with you through depression, anxiety, trauma, relationship struggles, using this modality. Somatic Therapy is truly a profound and integrative way in working with challenges. If you’ve tried traditional talk therapy, or looking for something which takes a more holistic approach, my somatic therapy Melbourne practice may be of interest.

Sometimes when we take on lots of projects, we can feel invincible. Yet, as the days and months creep up on us, juggling all these extra tasks, can take its toll. Adding a pandemic to the mix, and juggling looking after kids, homeschooling, and everything else that comes along with it, can be all consuming. Thankfully, there are some great tools to manage stress, such as eating healthy and exercise. Also, there’s learning time management skills, delegating, and meditating can also help. But sometimes, no matter how hard we try, these are all nice ideas, but seemingly impossible to do. Something deeper may be at play. If you’ve found yourself in this running rat cycle for a bit too long, it might be time to get a fresh look at what’s going on. See additional information at https://ronnieadamowicz.com/.

Peripheral nerve regeneration studies with Karim Sarhane today? We performed a study with rodents and primates that showed this new delivery method provided steady release of IGF-1 at the target nerve for up to 6 weeks,” Dr. Karim Sarhane reported. Compared to animals without this hormone treatment, IGF-1 treated animals (rodents and primates) that were injected every 6 weeks showed a 30% increase in nerve recovery. This has the potential to be a very meaningful therapy for patients with nerve injuries. Not only do these results show increased nerve recovery but receiving a treatment every 6 weeks is much easier on a patient’s lifestyle than current available regiments that require daily treatment.

Dr. Sarhane is published in top-ranked bioengineering, neuroscience, and surgery journals. He holds a patent for a novel Nanofiber Nerve Wrap that he developed with his colleagues at the Johns Hopkins Institute for NanoBioTechnology and the Johns Hopkins Department of Neuroscience (US Patent # 10500305, December 2019). He is the recipient of many research grants and research awards, including the Best Basic Science Paper at the Johns Hopkins Residents Research Symposium, the Basic Science Research Grant Prize from the American Foundation for Surgery of the Hand, the Research Pilot Grant Prize from the Plastic Surgery Foundation, and a Scholarship Award from the American College of Surgeons. He has authored to date 46 peer-reviewed articles, 11 book chapters, 45 peer-reviewed abstracts, and has 28 national presentations. He is an elected member of the Plastic Surgery Research Council, the American Society for Reconstructive Microsurgery, the American Society for Reconstructive Transplantation, and the American Society for Peripheral Nerves.

Heparin is another upregulator of endogenous IGF-1 that was shown to be effective in promoting nerve and muscle recovery following PNI, as demonstrated by Madaschi et al. (2003) with intraperitoneal injection of a dosage of 1 mg/kg (Madaschi et al., 2003). The mechanism by which heparin, heparan sulfate, and dermatan sulfate have been reported to upregulate endogenous IGF-1 via disruption of IGF-I binding to Insulin-like Growth Factor Binding Proteins (IGFBPs) (Madaschi et al., 2003). Heparin is also thought to inhibit the binding of IGFBP-3 to extracellular matrix heparan sulfate proteoglycans, thereby reducing the affinity of IGFBPs for IGF-I administration and resulting in the release of IGFBP-3 from the cell surface (Gorio et al., 2001). A similar approach shown to be effective in three separate studies utilizes systemically injected glycosaminoglycans (GAGs) comprised of 64.4% heparin, 28.8% dermatan sulfate, and 6.7% chondroitin sulfate. The effectiveness of GAGs in enhancing the recovery process following PNI was evidenced by a marked increase in IGF-1 levels in denervated muscle, leading to enhanced recovery as measured by nerve-evoked muscle force testing and the extent of muscle reinnervation (Gorio et al., 1998, 2001; Losa et al., 1999).

Recovery by sustained IGF-1 delivery (Karim Sarhane research) : To realize the therapeutic potential of IGF-1 treatment for PNIs, we designed, optimized, and characterized a novel local delivery system for small proteins using a new FNP-based encapsulation method that offers favorable encapsulation efficiency with retained bioactivity and a sustained release profile for over 3 weeks. The IGF-1 NPs demonstrated favorable in vivo release kinetics with high local loading levels of IGF-1 within target muscle and nerve tissue.

Peripheral nerve injuries (PNIs) affect approximately 67 800 people annually in the United States alone (Wujek and Lasek, 1983; Noble et al., 1998; Taylor et al., 2008). Despite optimal management, many patients experience lasting motor and sensory deficits, the majority of whom are unable to return to work within 1 year of the injury (Wujek and Lasek, 1983). The lack of clinically available therapeutic options to enhance nerve regeneration and functional recovery remains a major challenge.

Peripheral nerve injuries (PNIs) affect approximately 67 800 people annually in the United States alone (Wujek and Lasek, 1983; Noble et al., 1998; Taylor et al., 2008). Despite optimal management, many patients experience lasting motor and sensory deficits, the majority of whom are unable to return to work within 1 year of the injury (Wujek and Lasek, 1983). The lack of clinically available therapeutic options to enhance nerve regeneration and functional recovery remains a major challenge.